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A Phase 3b, Randomized, Open-label Study of the Antiviral Activity and Safety of Dolutegravir Compared to Lopinavir/Ritonavir Both Administered With Dual Nucleoside Reverse Transcriptase Inhibitor Therapy in HIV-1 Infected Adult Subjects With Treatment Failure on First Line Therapy

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A Phase 3b, Randomized, Open-label Study of the Antiviral Activity and Safety of Dolutegravir Compared to Lopinavir/Ritonavir Both Administered With Dual Nucleoside Reverse Transcriptase Inhibitor Therapy in HIV-1 Infected Adult Subjects With Treatment Failure on First Line Therapy

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 15 Mar 2023

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At a glance

  • Drugs Dolutegravir (Primary) ; Lopinavir/ritonavir; Nucleoside reverse transcriptase inhibitors
  • Indications HIV-1 infections
  • Focus Registrational; Therapeutic Use
  • Acronyms DAWNING
  • Sponsors ViiV Healthcare

    • Most Recent Events

    • 23 Feb 2022 Status changed from active, no longer recruiting to completed.
    • 28 Jan 2022 Planned End Date changed from 30 Nov 2021 to 28 Jan 2022.
    • 25 Oct 2021 Results of post-hoc analysis published in the Antimicrobial Agents and Chemotherapy.

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