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A Phase 3, Randomized, Open-Label Study of Nivolumab Combined with Ipilimumab Versus Sunitinib Monotherapy in Subjects with Previously Untreated, Advanced or Metastatic Renal Cell Carcinoma

Trial Profile

A Phase 3, Randomized, Open-Label Study of Nivolumab Combined with Ipilimumab Versus Sunitinib Monotherapy in Subjects with Previously Untreated, Advanced or Metastatic Renal Cell Carcinoma

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 01 Jul 2025

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At a glance

  • Drugs Ipilimumab (Primary) ; Nivolumab (Primary) ; Sunitinib
  • Indications Clear cell sarcoma; Renal cell carcinoma
  • Focus Registrational; Therapeutic Use
  • Acronyms CheckMate 214
  • Sponsors Bristol-Myers Squibb

Most Recent Events

  • 25 May 2025 Status changed from discontinued to completed.
  • 04 Jun 2024 Results (n=255) assessing performance of biomarkers in patients with mccRCC treated with nivolumab plus ipilimumab versus sunitinib using data from this trial presented at the 60th Annual Meeting of the American Society of Clinical Oncology
  • 03 Jun 2024 Results investigating whether HRQoL scores can predict OS of patients with 5 years follow-up assessed published in the Oncologist

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