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A randomized, single-blinded, multicenter, phase IV study to compare systemic VEGF protein dynamics following monthly intravitreal injections of 0.5 mg ranibizumab versus 2 mg aflibercept until study week 12 in patients with visual impairment due to diabetic macular edema

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Trial Profile

A randomized, single-blinded, multicenter, phase IV study to compare systemic VEGF protein dynamics following monthly intravitreal injections of 0.5 mg ranibizumab versus 2 mg aflibercept until study week 12 in patients with visual impairment due to diabetic macular edema

Status: Withdrawn prior to enrolment
Phase of Trial: Phase IV

Latest Information Update: 06 Nov 2021

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At a glance

  • Drugs Ranibizumab (Primary) ; Aflibercept
  • Indications Diabetic macular oedema
  • Focus Pharmacodynamics; Pharmacokinetics
  • Acronyms TIDE DME
  • Sponsors Novartis

Most Recent Events

  • 26 Oct 2016 Status changed from suspended to withdrawn prior to enrolment.
  • 15 Oct 2015 Planned End Date changed from 1 May 2016 to 1 Oct 2016 as per ClinicalTrials.gov record.
  • 15 Oct 2015 Planned primary completion date changed from 1 May 2016 to 1 Oct 2016 as per ClinicalTrials.gov record.

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