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An Interaction Study to Evaluate Changes in Blood Pressure Following 1, 1.5, 2, and 2.5 mg Riociguat Tid (Dose Titration) Compared to Placebo Treatment on the Background of Stable Sildenafil Pretreatment in Subjects With Symptomatic Pulmonary Arterial Hypertension

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Trial Profile

An Interaction Study to Evaluate Changes in Blood Pressure Following 1, 1.5, 2, and 2.5 mg Riociguat Tid (Dose Titration) Compared to Placebo Treatment on the Background of Stable Sildenafil Pretreatment in Subjects With Symptomatic Pulmonary Arterial Hypertension

Status: Discontinued
Phase of Trial: Phase II

Latest Information Update: 22 Dec 2023

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At a glance

  • Drugs Riociguat (Primary)
  • Indications Pulmonary arterial hypertension
  • Focus Therapeutic Use
  • Acronyms PATENT PLUS
  • Sponsors Bayer; Bayer HealthCare

Most Recent Events

  • 13 Nov 2023 Results of pooled post hoc analysis (n=741 from studies PATENT-1, PATENT PLUS, RESPITE, MOTION, REPLACE) assessing the impact of riociguat in patients with PAH and comorbidities presented at the American Heart Association Scientific Sessions 2023
  • 02 Jul 2019 This study is discontinued in Germany, Czech Republic, Poland and Italy, UK as reported by Eudra record.
  • 01 May 2015 According to results published in the European Respiratory Journal, the study was discontinued by Bayer HealthCare pharmaceuticals in agreement with the principal investigator due to hypotensive events, serious adverse events and deaths in the noncontrolled long-term extension phase in Dec 2012.

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