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An Interaction Study to Evaluate Changes in Blood Pressure Following 1, 1.5, 2, and 2.5 mg Riociguat Tid (Dose Titration) Compared to Placebo Treatment on the Background of Stable Sildenafil Pretreatment in Subjects With Symptomatic Pulmonary Arterial Hypertension

Trial Profile

An Interaction Study to Evaluate Changes in Blood Pressure Following 1, 1.5, 2, and 2.5 mg Riociguat Tid (Dose Titration) Compared to Placebo Treatment on the Background of Stable Sildenafil Pretreatment in Subjects With Symptomatic Pulmonary Arterial Hypertension

Status: Discontinued
Phase of Trial: Phase II

Latest Information Update: 02 Jul 2019

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At a glance

  • Drugs Riociguat (Primary)
  • Indications Pulmonary arterial hypertension
  • Focus Therapeutic Use
  • Acronyms PATENT PLUS
  • Sponsors Bayer; Bayer HealthCare
  • Most Recent Events

    • 02 Jul 2019 This study is discontinued in Germany, Czech Republic, Poland and Italy, UK as reported by Eudra record.
    • 01 May 2015 According to results published in the European Respiratory Journal, the study was discontinued by Bayer HealthCare pharmaceuticals in agreement with the principal investigator due to hypotensive events, serious adverse events and deaths in the noncontrolled long-term extension phase in Dec 2012.
    • 18 Sep 2014 New trial record
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