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An Open-label, Multicenter Study of Ambrisentan and a Phosphodiesterase Type-5 Inhibitor Combination Therapy in Subjects With Pulmonary Arterial Hypertension Who Have Demonstrated a Sub-Optimal Response to a Phosphodiesterase Type-5 Inhibitor

Trial Profile

An Open-label, Multicenter Study of Ambrisentan and a Phosphodiesterase Type-5 Inhibitor Combination Therapy in Subjects With Pulmonary Arterial Hypertension Who Have Demonstrated a Sub-Optimal Response to a Phosphodiesterase Type-5 Inhibitor

Status: Completed
Phase of Trial: Phase IV

Latest Information Update: 01 May 2017

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At a glance

  • Drugs Ambrisentan (Primary)
  • Indications Pulmonary arterial hypertension
  • Focus Therapeutic Use
  • Sponsors Gilead Sciences
  • Most Recent Events

    • 31 Aug 2018 Biomarkers information updated
    • 01 May 2017 Primary endpoint (Change From Baseline in Pulmonary Vascular Resistance (PVR), Last Observation Carried Forward (LOCF)) has been met. (Change From Baseline in Pulmonary Vascular Resistance (PVR), Last Observation Carried Forward (LOCF))
    • 01 May 2017 Results (n=33) assessing safety and efficacy of addition of ambrisentan in patients who received ambrisentan and did not receive placebo, published in the Respiratory Medicine
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