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A Randomized, Double-Blind, Placebo- and Positive-Controlled, Single-Dose, Four-Way Crossover Study to Evaluate the Effects of Ibrutinib on Cardiac Repolarization in Healthy Subjects

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Trial Profile

A Randomized, Double-Blind, Placebo- and Positive-Controlled, Single-Dose, Four-Way Crossover Study to Evaluate the Effects of Ibrutinib on Cardiac Repolarization in Healthy Subjects

Status: Discontinued
Phase of Trial: Phase I

Latest Information Update: 14 Jan 2020

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At a glance

  • Drugs Ibrutinib (Primary) ; Moxifloxacin
  • Indications B-cell lymphoma; Breast cancer; Chronic lymphocytic leukaemia; Diffuse large B cell lymphoma; Follicular lymphoma; Graft-versus-host disease; Hairy cell leukaemia; Mantle-cell lymphoma; Marginal zone B-cell lymphoma; Multiple myeloma; Non-Hodgkin's lymphoma; Waldenstrom's macroglobulinaemia
  • Focus Adverse reactions
  • Sponsors Janssen Research & Development; Pharmacyclics

    • Most Recent Events

    • 01 Dec 2017 Results assessing effect of ibrutinib at therapeutic and supratherapeutic exposures on cardiac repolarization published in the Cancer Chemotherapy and Pharmacology
    • 01 Dec 2017 Status changed to discontinued.
    • 27 Jul 2015 Status changed from recruiting to completed as per ClinicalTrials.gov record.

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