A Phase I Pharmacokinetic, Pharmacodynamic and Feasibility Study of Crenolanib in Combination With Sorafenib in Patients With Refractory or Relapsed Hematologic Malignancies (ARO-008)

Status: Completed

Phase of Trial: Phase I

Latest Information Update: 01 Apr 2022

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At a glance

Drugs Crenolanib (Primary) ; Sorafenib (Primary) ; Cytarabine; Hydrocortisone; Methotrexate
Indications Acute myeloid leukaemia; Haematological malignancies
Focus Adverse reactions

28 Mar 2022 Results assessing safety, activity, and emergence of FLT3-kinase domain (KD) mutations with combination therapy of crenolanib and sorafenib in acute myeloid leukemia (AML) with FLT3-internal tandem duplication published in the Clinical Cancer Research
02 Oct 2017 Status changed from active, no longer recruiting to completed.
06 Dec 2016 Results (n=7) presented at the 58th Annual Meeting and Exposition of the American Society of Hematology

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