Trial Profile

A Phase 1, Multiple-Dose, Dose-Escalation Trial of PT2385 Tablets, a HIF-2α Inhibitor, in Patients With Advanced Clear Cell Renal Cell Carcinoma

Status: Active, no longer recruiting

Phase of Trial: Phase I

Latest Information Update: 19 Jun 2024

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At a glance

Drugs Belzutifan (Primary) ; Cabozantinib (Primary) ; Nivolumab (Primary) ; PT 2385 (Primary)
Indications Renal cell carcinoma
Focus Adverse reactions; First in man
Sponsors Peloton Therapeutics

Most Recent Events

14 Jun 2024 Planned End Date changed from 30 Nov 2024 to 30 Nov 2026.
16 Apr 2024 As of Amendment 09 (29 Mar 2024), participants with advanced ccRCC will transition from MK-3795 to belzutifan in combination with nivolumab or belzutifan alone.
10 Jan 2024 Planned End Date changed from 30 Nov 2023 to 30 Nov 2024.

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