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A Phase II, Open-Label, Multicenter Study of Vemurafenib plus Cobimetinib (GDC-0973) in Unresectable Stage IIIc or Metastatic Melanoma; Response Monitoring and Resistance Prediction with Positron Emission Tomography and Tumor Characteristics.

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Trial Profile

A Phase II, Open-Label, Multicenter Study of Vemurafenib plus Cobimetinib (GDC-0973) in Unresectable Stage IIIc or Metastatic Melanoma; Response Monitoring and Resistance Prediction with Positron Emission Tomography and Tumor Characteristics.

Status: Discontinued
Phase of Trial: Phase II

Latest Information Update: 29 Jan 2024

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At a glance

  • Drugs Cobimetinib (Primary) ; F-18 fluorothymidine (Primary) ; Vemurafenib (Primary) ; Fludeoxyglucose F-18
  • Indications Malignant melanoma
  • Focus Diagnostic use; Therapeutic Use
  • Acronyms REPOSIT

Most Recent Events

  • 01 Feb 2024 Results assessing whether (early) PERCIST response monitoring with 18 F-FDG PET/CT is predictive for progression-free survival (PFS) in unresectable stage III or IV melanoma patients treated with BRAF/MEK inhibitor (MEKi) and to define dissemination patterns at progression with a lesion-based evaluation in direct comparison to baseline to improve our understanding of 18 F-FDG PET/CT during BRAF/MEKi, were published in the Clinical Nuclear Medicine.
  • 02 Dec 2022 Status changed from recruiting to discontinued.
  • 01 May 2018 Planned primary completion date changed from 1 Dec 2017 to 1 Dec 2018.

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