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Effects of Sympathicomimetic Agonists on the Disease Course and Mutant Allele Burden in Patients With JAK2-mutated Myeloproliferative Neoplasms. A Multicenter Phase II Trial.

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Trial Profile

Effects of Sympathicomimetic Agonists on the Disease Course and Mutant Allele Burden in Patients With JAK2-mutated Myeloproliferative Neoplasms. A Multicenter Phase II Trial.

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 06 Nov 2021

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At a glance

  • Drugs Mirabegron (Primary)
  • Indications Myelofibrosis; Myeloproliferative disorders; Polycythaemia vera; Thrombocytopenia
  • Focus Therapeutic Use

    • Most Recent Events

    • 28 Dec 2016 Status changed from active, no longer recruiting to completed.
    • 06 Dec 2016 Primary endpoint (Reduction in the burden of mutated alleles of 50% at 24 weeks) has not been met, according to results presented at the 58th Annual Meeting and Exposition of the American Society of Hematology.
    • 06 Dec 2016 Results presented at the 58th Annual Meeting and Exposition of the American Society of Hematology
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