Trial Profile

A Phase I Trial of VS-6766 (RO5126766) (a Dual RAF/MEK Inhibitor) Exploring Intermittent, Oral Dosing Regimens in Patients With Solid Tumours or Multiple Myeloma, With an Expansion to Explore Intermittent Dosing in Combination With Everolimus

Status: Completed

Phase of Trial: Phase I

Latest Information Update: 02 Feb 2026

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At a glance

Drugs Avutometinib (Primary) ; Everolimus
Indications Adenocarcinoma; Carcinoma; Colorectal cancer; Gynaecological cancer; Lung cancer; Malignant melanoma; Mesothelioma; Multiple myeloma; Non-small cell lung cancer; Ovarian cancer; Pancreatic cancer; Prostate cancer; Solid tumours; Thyroid cancer
Focus Adverse reactions; Proof of concept
Acronyms RAF/MEK

29 Jan 2026 Status changed from active, no longer recruiting to completed.
17 Aug 2025 Planned End Date changed from 1 Jun 2025 to 1 Sep 2025.
17 Aug 2025 Planned primary completion date changed from 1 Jun 2025 to 1 Sep 2025.

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