Trial Profile

A Phase I/II Trial of the Bruton's Tyrosine Kinase (BTK) Inhibitor, Ibrutinib, in Patients with Newly Diagnosed or Refractory/Recurrent Primary Central Nervous System Lymphoma (PCNSL) and Refractory/Recurrent Secondary Central Nervous System Lymphoma (SCNSL)

Status: Completed

Phase of Trial: Phase I/II

Latest Information Update: 05 Feb 2026

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At a glance

Drugs Ibrutinib (Primary) ; Filgrastim; Methotrexate; Procarbazine; Rituximab
Indications CNS cancer; Diffuse large B cell lymphoma
Focus Adverse reactions; Therapeutic Use

02 Feb 2026 Status changed from recruiting to completed.
06 Jun 2023 Planned End Date changed from 1 Dec 2023 to 1 Dec 2026.
06 Jun 2023 Planned primary completion date changed from 1 Dec 2023 to 1 Dec 2026.

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