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An Open Label, Single Group Assignment Design Study to Correlate Soluble ST2 With Clinical, Endoscopic and Histological Activity in Moderate to Severe Ulcerative Colitis Patients Under Golimumab.

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Trial Profile

An Open Label, Single Group Assignment Design Study to Correlate Soluble ST2 With Clinical, Endoscopic and Histological Activity in Moderate to Severe Ulcerative Colitis Patients Under Golimumab.

Status: Completed
Phase of Trial: Phase IV

Latest Information Update: 13 May 2022

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At a glance

  • Drugs Golimumab (Primary) ; Glucocorticoids; Immunosuppressants
  • Indications Ulcerative colitis
  • Focus Biomarker; Diagnostic use
  • Acronyms EVOLUTION
  • Sponsors Merck Sharp & Dohme

    • Most Recent Events

    • 24 Oct 2018 Primary endpoint has not been met. (Correlation of Serum Soluble ST2 Levels With Histological Activity (Assessed by Geboes Index) at Week 6) according to results presented at the 26th United European Gastroenterology Week.
    • 24 Oct 2018 Primary endpoint has been met. (Correlation of Serum Soluble Human Suppression of Tumorigenicity 2 (ST2) Levels With Endoscopic Activity of Disease (Assessed by Endoscopy Subscore of Mayo Score) at Week 6) according to results presented at the 26th United European Gastroenterology Week.
    • 24 Oct 2018 Results assessing non-invasive serum biomarkers to assess intestinal inflammation and predict clinical response, presented at the 26th United European Gastroenterology Week.

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