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A phase Ib study to assess the safety and tolerability of oral Ruxolitinib in combination with 5-azacitidine in patients with advanced phase myeloproliferative neoplasms (MPN), including myelodysplastic syndromes (MDS) or acute myeloid leukaemia (AML) arising from MPN

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Trial Profile

A phase Ib study to assess the safety and tolerability of oral Ruxolitinib in combination with 5-azacitidine in patients with advanced phase myeloproliferative neoplasms (MPN), including myelodysplastic syndromes (MDS) or acute myeloid leukaemia (AML) arising from MPN

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 17 Feb 2025

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At a glance

  • Drugs Azacitidine (Primary) ; Ruxolitinib (Primary)
  • Indications Acute myeloid leukaemia; Essential thrombocythaemia; Myelodysplastic syndromes; Myelofibrosis; Myeloproliferative disorders; Polycythaemia vera
  • Focus Adverse reactions
  • Acronyms PHAZAR

Most Recent Events

  • 03 Jan 2022 Status changed from active, no longer recruiting to completed.
  • 05 Nov 2021 Planned End Date changed from 31 Oct 2020 to 31 Dec 2021.
  • 05 Nov 2021 Status changed from completed to active, no longer recruiting.

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