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An Open-Label, Multicenter, Dose-Escalation Phase I Study to Evaluate the Safety, Pharmacokinetics, and Therapeutic Activity of RO6958688, A Novel T-cell Bispecific Antibody That Targets the Human Carcinoembryonic Antigen (CEA) on Tumor Cells and CD3 on T Cells, Administered Intravenously in Patients With Locally Advanced and/or Metastatic CEA(+) Solid Tumors

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Trial Profile

An Open-Label, Multicenter, Dose-Escalation Phase I Study to Evaluate the Safety, Pharmacokinetics, and Therapeutic Activity of RO6958688, A Novel T-cell Bispecific Antibody That Targets the Human Carcinoembryonic Antigen (CEA) on Tumor Cells and CD3 on T Cells, Administered Intravenously in Patients With Locally Advanced and/or Metastatic CEA(+) Solid Tumors

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 06 Nov 2021

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At a glance

  • Drugs Cibisatamab (Primary) ; Obinutuzumab; Tocilizumab
  • Indications Colorectal cancer; Gastrointestinal cancer; Solid tumours
  • Focus Adverse reactions; First in man; Pharmacodynamics; Pharmacokinetics
  • Sponsors Roche

    • Most Recent Events

    • 04 Dec 2019 Status changed from active, no longer recruiting to completed.
    • 17 Oct 2019 Planned End Date changed from 16 Aug 2019 to 1 Nov 2019.
    • 17 Oct 2019 Planned primary completion date changed from 16 Aug 2019 to 1 Nov 2019.

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