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Phase 1, Multicenter, Open-label, Dose-escalation, Combination Study of Marizomib and Bevacizumab in Bevacizumab-Naïve Subjects With WHO Grade IV Malignant Glioma Followed by Phase 2 Studies of Single Agent Marizomib and Combination Marizomib and Bevacizumab, and Phase 1 Dose-Escalation Study of Enterally-administered Marizomib With Bevacizumab

Trial Profile

Phase 1, Multicenter, Open-label, Dose-escalation, Combination Study of Marizomib and Bevacizumab in Bevacizumab-Naïve Subjects With WHO Grade IV Malignant Glioma Followed by Phase 2 Studies of Single Agent Marizomib and Combination Marizomib and Bevacizumab, and Phase 1 Dose-Escalation Study of Enterally-administered Marizomib With Bevacizumab

Status: Completed
Phase of Trial: Phase I/II

Latest Information Update: 09 Jun 2022

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At a glance

  • Drugs Bevacizumab (Primary) ; Marizomib (Primary) ; Marizomib (Primary)
  • Indications Glioblastoma; Glioma; Gliosarcoma
  • Focus Adverse reactions; Biomarker; Pharmacokinetics; Proof of concept; Therapeutic Use
  • Sponsors Celgene Corporation; Triphase Accelerator Corporation
  • Most Recent Events

    • 29 Oct 2021 Status changed from active, no longer recruiting to completed.
    • 03 Dec 2020 Planned End Date changed from 9 Oct 2020 to 30 Jun 2021.
    • 03 Dec 2020 Planned primary completion date changed from 9 Oct 2020 to 30 Jun 2021.

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