Phase 1, Multicenter, Open-label, Dose-escalation, Combination Study of Marizomib and Bevacizumab in Bevacizumab-Naïve Subjects With WHO Grade IV Malignant Glioma Followed by Phase 2 Studies of Single Agent Marizomib and Combination Marizomib and Bevacizumab, and Phase 1 Dose-Escalation Study of Enterally-administered Marizomib With Bevacizumab
Latest Information Update: 09 Jun 2022
At a glance
- Drugs Bevacizumab (Primary) ; Marizomib (Primary) ; Marizomib (Primary)
- Indications Glioblastoma; Glioma; Gliosarcoma
- Focus Adverse reactions; Biomarker; Pharmacokinetics; Proof of concept; Therapeutic Use
- Sponsors Celgene Corporation; Triphase Accelerator Corporation
- 29 Oct 2021 Status changed from active, no longer recruiting to completed.
- 03 Dec 2020 Planned End Date changed from 9 Oct 2020 to 30 Jun 2021.
- 03 Dec 2020 Planned primary completion date changed from 9 Oct 2020 to 30 Jun 2021.