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A Phase I/II Study of MCLA-128, a Full Length IgG1 Bispecific Antibody Targeting HER2 and HER3, in Patients With Solid Tumors (eNRGy)

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Trial Profile

A Phase I/II Study of MCLA-128, a Full Length IgG1 Bispecific Antibody Targeting HER2 and HER3, in Patients With Solid Tumors (eNRGy)

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 24 Nov 2025

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At a glance

  • Drugs Zenocutuzumab (Primary)
  • Indications Adenocarcinoma; Advanced breast cancer; Carcinoma; Cholangiocarcinoma; Colorectal cancer; Endometrial cancer; Gastric cancer; Liver metastases; Non-small cell lung cancer; Oesophageal cancer; Ovarian cancer; Pancreatic cancer; Pancreatic ductal carcinoma; Solid tumours
  • Focus First in man; Registrational; Therapeutic Use
  • Acronyms eNRGy
  • Sponsors Merus

Most Recent Events

  • 23 Oct 2025 Results presented in the Partner Therapeutics media release.
  • 23 Oct 2025 According to Partner Therapeutics media release, result from this study will serve as the basis for a supplemental Biologics License Application (sBLA) that will be submitted to FDA in 2026.
  • 23 Oct 2025 According to Partner Therapeutics media release, result data from this study will be presented at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in Boston.

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