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A Randomized, Double-blind, Placebo-controlled Study to Assess the Effects of Bempedoic Acid (ETC-1002) on the Occurrence of Major Cardiovascular Events in Patients With, or at High Risk for, Cardiovascular Disease Who Are Statin Intolerant

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Trial Profile

A Randomized, Double-blind, Placebo-controlled Study to Assess the Effects of Bempedoic Acid (ETC-1002) on the Occurrence of Major Cardiovascular Events in Patients With, or at High Risk for, Cardiovascular Disease Who Are Statin Intolerant

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 15 May 2025

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At a glance

  • Drugs Bempedoic acid (Primary)
  • Indications Cardiovascular disorders; Coronary artery disease; Hypercholesterolaemia; Intracranial-Arteriosclerosis; Peripheral arterial disorders
  • Focus Registrational; Therapeutic Use
  • Acronyms CLEAR Outcomes; CVOT
  • Sponsors Esperion Therapeutics

Most Recent Events

  • 08 May 2025 According to an Esperion Therapeutics media release, in Q4 2024, Esperion submitted New Drug Submissions to Health Canada for both NEXLETOL and NEXLIZET1. Under this agreement, HLS will be responsible for obtaining Health Canada approval, which is expected by the end of 2025.
  • 06 May 2025 According to an Esperion Therapeutics media release, post-hoc analysis data from this study was published in Journal of Clinical Lipidology.
  • 18 Nov 2024 According to an Esperion Therapeutics media release, data from this trial was presented at the 2024 American Heart Association (AHA) Scientific Sessions, which took place from November 16-18, 2024, in Chicago, IL.

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