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A Phase 3 Open Label Study to Evaluate the Long-term Safety and Tolerability of ALKS 8700 in Adults With Relapsing Remitting Multiple Sclerosis

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Trial Profile

A Phase 3 Open Label Study to Evaluate the Long-term Safety and Tolerability of ALKS 8700 in Adults With Relapsing Remitting Multiple Sclerosis

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 12 Dec 2024

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At a glance

  • Drugs Diroximel-fumarate (Primary)
  • Indications Multiple sclerosis
  • Focus Adverse reactions; Registrational
  • Acronyms EVOLVE-1; EVOLVE-MS-1
  • Sponsors Biogen

    • Most Recent Events

    • 01 Dec 2023 Results of final outcomes , published in the Multiple Sclerosis Journal
    • 13 Oct 2023 Results comparing cohorts from the EVOLVE-MS-1study for DRF and the DECIDE study for IFN beta-1a assessing the efficacy and safety of DRF and IFN beta-1a in adults with relapsing-remitting multiple sclerosis, presented at the 9th Triennial joint meeting of Americas Committee for Treatment and Research in Multiple Sclerosis and the European Committee for Treatment and Research in Multiple Sclerosis.
    • 13 Oct 2023 Results of Subgroup analysis, determining whether lymphopenia or magni-tude of ALC decline is correlated with DRF efficacy , presented at the 9th Triennial joint meeting of Americas Committee for Treatment and Research in Multiple Sclerosis and the European Committee for Treatment and Research in Multiple Sclerosis

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