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A Double-Blind, Placebo-Controlled, Dose-Escalating, Phase 1 Study to Determine the Safety, Tolerability, Pharmacokinetics and Effect of Circulating Alpha-1 Antitrypsin Levels of ARC-AAT in Healthy Volunteer Subjects and in Patients With Alpha-1 Antitrypsin Deficiency (AATD)

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Trial Profile

A Double-Blind, Placebo-Controlled, Dose-Escalating, Phase 1 Study to Determine the Safety, Tolerability, Pharmacokinetics and Effect of Circulating Alpha-1 Antitrypsin Levels of ARC-AAT in Healthy Volunteer Subjects and in Patients With Alpha-1 Antitrypsin Deficiency (AATD)

Status: Discontinued
Phase of Trial: Phase I

Latest Information Update: 17 Sep 2021

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At a glance

  • Drugs ARC AAT (Primary) ; Diphenhydramine
  • Indications Alpha 1-antitrypsin deficiency; Liver disorders
  • Focus Adverse reactions; First in man; Pharmacokinetics; Therapeutic Use
  • Sponsors Arrowhead Pharmaceuticals

Most Recent Events

  • 20 Mar 2018 Results published in the Journal of Hepatology.
  • 24 Apr 2017 According to an Arrowhead Pharmaceuticals media release, data from this trial presented at The International Liver Congress 2017 (ILC), the annual meeting of the European Association for the Study of the Liver (EASL).
  • 04 Jan 2017 Planned End Date changed from 1 Mar 2017 to 1 Feb 2017.

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