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A Safety and Preliminary Efficacy Trial of Pembrolizumab (MK-3475) in Children With Recurrent, Progressive or Refractory Diffuse Intrinsic Pontine Glioma (DIPG), Non-Brainstem High-Grade Gliomas (NB-HGG), Ependymoma, Medulloblastoma or Hypermutated Brain Tumors

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A Safety and Preliminary Efficacy Trial of Pembrolizumab (MK-3475) in Children With Recurrent, Progressive or Refractory Diffuse Intrinsic Pontine Glioma (DIPG), Non-Brainstem High-Grade Gliomas (NB-HGG), Ependymoma, Medulloblastoma or Hypermutated Brain Tumors

Status: Active, no longer recruiting
Phase of Trial: Phase I

Latest Information Update: 07 Mar 2025

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At a glance

  • Drugs Pembrolizumab (Primary)
  • Indications Brain cancer; Diffuse intrinsic pontine glioma; Ependymoma; Glioma; Medulloblastoma
  • Focus Adverse reactions; Therapeutic Use

    • Most Recent Events

    • 03 Feb 2025 Planned End Date changed from 31 Dec 2026 to 21 Dec 2025.
    • 03 Feb 2025 Planned primary completion date changed from 31 Dec 2026 to 21 Dec 2025.
    • 04 Dec 2024 Status changed from recruiting to active, no longer recruiting.

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