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An Open-label Phase 1b Study of PF-04449913 (Glasdegib) in Combination With Azacitidine in Patients With Previously Untreated Higher-Risk Myelodysplastic Syndrome, Acute Myeloid Leukemia, or Chronic Myelomonocytic Leukemia

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Trial Profile

An Open-label Phase 1b Study of PF-04449913 (Glasdegib) in Combination With Azacitidine in Patients With Previously Untreated Higher-Risk Myelodysplastic Syndrome, Acute Myeloid Leukemia, or Chronic Myelomonocytic Leukemia

Status: Completed
Phase of Trial: Phase I/II

Latest Information Update: 21 Jan 2024

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At a glance

  • Drugs Azacitidine (Primary) ; Glasdegib (Primary)
  • Indications Acute myeloid leukaemia; Chronic myelomonocytic leukaemia; Myelodysplastic syndromes
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms BRIGHT 1012
  • Sponsors Pfizer

Most Recent Events

  • 01 Aug 2022 Results published in the Annals of Hematology
  • 14 Mar 2022 Status changed from active, no longer recruiting to completed.
  • 24 Jan 2022 Planned End Date changed from 21 Dec 2021 to 6 Feb 2022.

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