Either you have JavaScript disabled or your browser does not support Javascript . To work properly, this page requires JavaScript to be enabled.
How to enable JavaScript in your browser?

A Phase 2, Double-Blinded, Randomized, Placebo-Controlled, Dose-Escalation Study to Examine the Safety, Tolerability, Pharmacokinetics and Antiviral Activity of ISIS 505358 in Treatment-Naïve Patients With Chronic HBV Infection

Next Previous
Trial Profile

A Phase 2, Double-Blinded, Randomized, Placebo-Controlled, Dose-Escalation Study to Examine the Safety, Tolerability, Pharmacokinetics and Antiviral Activity of ISIS 505358 in Treatment-Naïve Patients With Chronic HBV Infection

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 28 Dec 2023

Price :
$35 *
Note:
  • Adis is an information provider.
  • Final gross price and currency may vary according to local VAT and billing address.
  • Your purchase entitles you to full access to the information contained in our trial profile at the time of purchase.
  • A link to download a PDF version of the trial profile will be included in your email receipt.

At a glance

  • Drugs Bepirovirsen (Primary) ; Entecavir; Tenofovir disoproxil fumarate
  • Indications Hepatitis B
  • Focus Adverse reactions
  • Sponsors GlaxoSmithKline; GSK

Most Recent Events

  • 14 Nov 2023 Results evaluating patients peripheral blood mononuclear cells (PBMC) post-hoc using deep immunophenotyping by high parameter flow cytometry from this study, presented at The Liver Meeting 2023: 74th Annual Meeting of the American Association for the Study of Liver Diseases
  • 26 Jun 2022 Results of pooled analysis (Phase 1 study (GSK 213725) in healthy volunteers, Phase 2a (GSK 205695) and Phase 2b (GSK 209668) studies) assessing BPV systemic exposures and effect on changes in HBsAg and ALT and to identify patient characteristics that may be predictors of exposure and response to treatment, presented at The International Liver Congress 2022.
  • 26 Jun 2022 Results of post-hoc analysis evaluating the changes in soluble proteins measured in this study, presented at The International Liver Congress 2022.

You need to be a logged in or subscribed to view this content

Request demo (opens in a new window)
If your organization or you do not have a subscription, try one of the following: If your organization has a subscription, there are several access options, even while working remotely:
  • Working within your organization’s network
  • with username/password or try to via your institution
  • Persisted access using your organization’s identifier stored in your user browser for 90 days
Back to top