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A Study to Evaluate Imetelstat (GRN163L) in Transfusion-Dependent Subjects with IPSS Low or Intermediate-1 Risk Myelodysplastic Syndrome (MDS) that is Relapsed/Refractory to Erythropoiesis-Stimulating Agent (ESA) Treatment

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Trial Profile

A Study to Evaluate Imetelstat (GRN163L) in Transfusion-Dependent Subjects with IPSS Low or Intermediate-1 Risk Myelodysplastic Syndrome (MDS) that is Relapsed/Refractory to Erythropoiesis-Stimulating Agent (ESA) Treatment

Status: Active, no longer recruiting
Phase of Trial: Phase II/III

Latest Information Update: 07 Jan 2026

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At a glance

  • Drugs Imetelstat (Primary)
  • Indications Myelodysplastic syndromes
  • Focus Registrational; Therapeutic Use
  • Acronyms IMerge
  • Sponsors Geron Corporation; Janssen Research & Development; Janssen-Cilag

Most Recent Events

  • 08 Dec 2025 According to a Geron Corporation media release, data from this study presented at the 67th American Society of Hematology (ASH) 2025 Annual Meeting being held in Orlando, FL.
  • 03 Nov 2025 According to a Geron Corporation media release,data from this trial will be presented at 67th American Society of Hematology (ASH) 2025 Annual Meeting, to be held December 6-9, 2025 in Orlando, FL.
  • 07 May 2025 According to a Geron Corporation media release, Research and development expenses for the three months ended March 31, 2025, were $15.1 million, compared to $29.4 million for the same period in 2024. The decrease was primarily due to the wind down of clinical trial costs associated with a decrease of activity in our Phase 3 IMerge MDS study after FDA approval of RYTELO in 2024.

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