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A Phase I Trial Assessing Several Schedules of Oral S-1 in Combination With a Fixed Dose of Oxaliplatin and Irinotecan in Patients With Advanced or Metastatic Digestive Adenocarcinoma as First- or Second-line Treatment

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A Phase I Trial Assessing Several Schedules of Oral S-1 in Combination With a Fixed Dose of Oxaliplatin and Irinotecan in Patients With Advanced or Metastatic Digestive Adenocarcinoma as First- or Second-line Treatment

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 06 Nov 2021

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At a glance

  • Drugs Gimeracil/oteracil/tegafur (Primary) ; Irinotecan (Primary) ; Oxaliplatin (Primary) ; Granulocyte colony-stimulating factors
  • Indications Adenocarcinoma; Anal cancer; Biliary cancer; Cholangiocarcinoma; Colorectal cancer; Gastric cancer; Gastrointestinal cancer; Liver cancer; Oesophageal cancer; Pancreatic cancer; Squamous cell cancer
  • Focus Adverse reactions
  • Acronyms SIRINOX
  • Sponsors Nordic Group

    • Most Recent Events

    • 20 Aug 2019 Status changed from recruiting to completed.
    • 05 Jun 2018 Results of S-1 plus irinotecan (n=14), presented at the 54th Annual Meeting of the American Society of Clinical Oncology
    • 16 Aug 2017 Planned End Date changed from 1 Dec 2016 to 1 Dec 2020.

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