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An Open-label, Single-arm, Phase I/II, Multicentre Study to Evaluate the Safety and Efficacy of the Combination of Dabrafenib, Trametinib and Palliative Radiotherapy in Patients with Unresectable (stage IIIc) and Metastatic (stage IV) BRAF V600E/K Mutation-positive Cutaneous Melanoma

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Trial Profile

An Open-label, Single-arm, Phase I/II, Multicentre Study to Evaluate the Safety and Efficacy of the Combination of Dabrafenib, Trametinib and Palliative Radiotherapy in Patients with Unresectable (stage IIIc) and Metastatic (stage IV) BRAF V600E/K Mutation-positive Cutaneous Melanoma

Status: Completed
Phase of Trial: Phase I/II

Latest Information Update: 29 Nov 2024

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At a glance

  • Drugs Dabrafenib (Primary) ; Trametinib (Primary)
  • Indications Malignant melanoma
  • Focus Adverse reactions
  • Acronyms CombiRT

Most Recent Events

  • 06 Apr 2022 Status changed from active, no longer recruiting to completed.
  • 11 Oct 2020 Planned End Date changed from 30 Jun 2020 to 1 Nov 2020.
  • 11 Oct 2020 Planned primary completion date changed from 1 Jun 2020 to 1 Nov 2020.

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