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An Open-label, Dose-ranging, Proof-of-Concept Study to Evaluate the Safety and Efficacy of Lonafarnib With Ritonavir-Boosting +/- Peginterferon Alfa-2a in Patients Chronically Infected With Delta Hepatitis (HDV) (LOWR-2)

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Trial Profile

An Open-label, Dose-ranging, Proof-of-Concept Study to Evaluate the Safety and Efficacy of Lonafarnib With Ritonavir-Boosting +/- Peginterferon Alfa-2a in Patients Chronically Infected With Delta Hepatitis (HDV) (LOWR-2)

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 23 Feb 2023

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At a glance

  • Drugs Lonafarnib (Primary) ; Peginterferon alfa-2a (Primary) ; Ritonavir (Primary)
  • Indications Hepatitis D
  • Focus Adverse reactions; Proof of concept; Therapeutic Use
  • Acronyms LOWR HDV-2; LOWR-2
  • Sponsors Eiger BioPharmaceuticals

Most Recent Events

  • 08 Nov 2022 Results of retrospective study (n=5; from Phase 2 LOWR 1 and LOWR 2 studies) assessing the effect of oral LNF based therapy of 3 to 12 months duration with long term follow up delineating durable off treatment biochemical and viral efficacy presented at The Liver Meeting 2022: 73rd Annual Meeting of the American Association for the Study of Liver Diseases
  • 03 Dec 2021 Results published in the Hepatology
  • 17 Apr 2018 Results published in the Media Release

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