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A Phase III, Randomized, Multicenter, Parallel-group, Non-inferiority Study Evaluating the Efficacy, Safety, and Tolerability of Switching to Dolutegravir Plus Rilpivirine From Current INI-, NNRTI-, or PI-based Antiretroviral Regimen in HIV-1-Infected Adults Who Are Virologically Suppressed (SWORD-1)

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Trial Profile

A Phase III, Randomized, Multicenter, Parallel-group, Non-inferiority Study Evaluating the Efficacy, Safety, and Tolerability of Switching to Dolutegravir Plus Rilpivirine From Current INI-, NNRTI-, or PI-based Antiretroviral Regimen in HIV-1-Infected Adults Who Are Virologically Suppressed (SWORD-1)

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 06 Sep 2024

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At a glance

  • Drugs Dolutegravir (Primary) ; Rilpivirine (Primary) ; Integrase inhibitors; Non-nucleoside reverse transcriptase inhibitors; Nucleoside reverse transcriptase inhibitors; Peptide hydrolase inhibitors
  • Indications HIV-1 infections
  • Focus Registrational; Therapeutic Use
  • Acronyms SWORD-1
  • Sponsors ViiV Healthcare

    • Most Recent Events

    • 10 Nov 2023 Status changed from active, no longer recruiting to completed.
    • 06 Jul 2023 This trial has been completed in Netherlands (End Date: 30 May 2023), according to European Clinical Trials Database record.
    • 05 Feb 2023 Results of pooled analysis from SWORD-1 and SWORD-2 assessing drug exposure and exposure-efficacy/safety relationships, published in the British Journal of Clinical Pharmacology

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