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Overcoming Drug Resistance in Metastatic Castration-resistant Prostate Cancer With Novel Combination of TGF-β Receptor Inhibitor LY2157299 and Enzalutamide: a Randomized Multi-site Phase II Study

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Trial Profile

Overcoming Drug Resistance in Metastatic Castration-resistant Prostate Cancer With Novel Combination of TGF-β Receptor Inhibitor LY2157299 and Enzalutamide: a Randomized Multi-site Phase II Study

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 13 Jun 2025

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At a glance

  • Drugs Galunisertib (Primary) ; Enzalutamide
  • Indications Prostate cancer
  • Focus Therapeutic Use

Most Recent Events

  • 06 Jun 2025 Planned primary completion date changed from 1 May 2025 to 1 Dec 2025.
  • 21 Oct 2024 Planned End Date changed from 1 Dec 2025 to 1 May 2026.
  • 21 Oct 2024 Planned primary completion date changed from 1 Oct 2024 to 1 May 2025.

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