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A Multicenter, Randomized, Double-blind, Parallel Group, Active-controlled Study to Evaluate the Efficacy and Safety of LCZ696 Compared to Enalapril on Morbidity and Mortality in Japanese Patients With Chronic Heart Failure and Reduced Ejection Fraction

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A Multicenter, Randomized, Double-blind, Parallel Group, Active-controlled Study to Evaluate the Efficacy and Safety of LCZ696 Compared to Enalapril on Morbidity and Mortality in Japanese Patients With Chronic Heart Failure and Reduced Ejection Fraction

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 12 Dec 2023

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At a glance

  • Drugs Sacubitril/valsartan (Primary) ; Enalapril
  • Indications Atrial fibrillation; Chronic heart failure; Hypertension; Myocardial infarction; Stroke
  • Focus Therapeutic Use
  • Acronyms PARALLEL-HF; SAVASAVA Study
  • Sponsors Novartis Pharma KK; Novartis Pharmaceuticals

    • Most Recent Events

    • 12 Nov 2023 Results of subgroup analysis, evaluating the efficacy and safety of sacubitril/valsartan according to baseline SBP tertiles in Japanese patients published in the Circulation Journal
    • 26 Aug 2023 Results (n=115) of an open-label extension (OLE) of PARALLEL-HF study assessing long-term safety with sacubitril/valsartan published in the Circulation Journal
    • 26 Mar 2021 Status changed from active, no longer recruiting to completed.

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