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A Phase 2, Open Label, Randomized, Dose Ranging, Safety, Efficacy, Pharmacokinetic and Pharmacodynamic Study of AG-348 in Adult Patients With Pyruvate Kinase Deficiency

Trial Profile

A Phase 2, Open Label, Randomized, Dose Ranging, Safety, Efficacy, Pharmacokinetic and Pharmacodynamic Study of AG-348 in Adult Patients With Pyruvate Kinase Deficiency

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 08 Dec 2020

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At a glance

  • Drugs Mitapivat (Primary) ; Mitapivat (Primary)
  • Indications Haemolytic anaemia; Pyruvate kinase deficiency of red cells
  • Focus Adverse reactions; Proof of concept
  • Acronyms DRIVE PK
  • Sponsors Agios Pharmaceuticals
  • Most Recent Events

    • 08 Dec 2020 Results of pooled pre-treatment baseline data from 3 clinical trials (DRIVE-PK, ACTIVATE and ACTIVATE-T), presented at the 62nd Annual Meeting and Exposition of the American Society of Hematology.
    • 01 Jul 2020 Planned End Date changed from 1 Apr 2025 to 1 May 2025.
    • 21 Jun 2020 Results of the extension phase presented at the 25th Congress of the European Haematology Association
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