Trial Profile

A Cancer Research UK Randomised, Double Blind, Placebo Controlled Phase IIa Trial of AMG 319 Given Orally as a Neoadjuvant Therapy in Patients With Human Papillomavirus (HPV) Positive and Negative Head and Neck Squamous Cell Carcinoma (HNSCC)

Status: Discontinued

Phase of Trial: Phase II

Latest Information Update: 06 Nov 2021

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At a glance

Drugs AMG 319 (Primary)
Indications Head and neck cancer; Human papillomavirus infections; Squamous cell cancer
Focus Adverse reactions; Pharmacodynamics

16 Jul 2018 Status changed from recruiting to discontinued.
05 Jun 2018 Results (n=22) quantifying immunological effects of AMG319 on the tumour microenvironment presented at the 54th Annual Meeting of the American Society of Clinical Oncology
05 Jan 2018 Planned primary completion date changed from 1 Oct 2019 to 1 Oct 2020.

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