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A Study to Assess the Effect of MK-7264 (AF-219) on Cough Reflex Sensitivity in Both Healthy and Chronic Cough Subjects

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Trial Profile

A Study to Assess the Effect of MK-7264 (AF-219) on Cough Reflex Sensitivity in Both Healthy and Chronic Cough Subjects

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 14 Dec 2023

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At a glance

  • Drugs Gefapixant (Primary)
  • Indications Cough
  • Focus Therapeutic Use
  • Acronyms Cough Challenge
  • Sponsors Afferent Pharmaceuticals

    • Most Recent Events

    • 25 Apr 2019 Primary endpoint has been not met. (Cough Reflex Sensitivity to Distilled Water inducing at least 5 coughs (C5) in Healthy Volunteers Who Received Gefapixant 100 mg and Placebo (Period 1 & Period 2 Combined)), as per results published in the European Respiratory Journal.
    • 25 Apr 2019 Primary endpoint has been met. (Cough Reflex Sensitivity to Distilled Water inducing at least 2 coughs (C2) in Healthy Volunteers Who Received Gefapixant 100 mg and Placebo (Period 1 & Period 2 Combined)), as per results published in the European Respiratory Journal.
    • 25 Apr 2019 Primary endpoint has been met. (Cough Reflex Sensitivity to Distilled Water in chronic cough Patients Who Received Gefapixant 100 mg and Placebo (Period 1 & Period 2 Combined)), as per results published in the European Respiratory Journal.
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