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A Randomized, Open Label, Multicenter Study of Cabazitaxel Versus an Androgen Receptor (AR)-Targeted Agent (Abiraterone or Enzalutamide) in mCRPC Patients Previously Treated With Docetaxel and Who Rapidly Failed a Prior AR-targeted Agent (CARD)

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Trial Profile

A Randomized, Open Label, Multicenter Study of Cabazitaxel Versus an Androgen Receptor (AR)-Targeted Agent (Abiraterone or Enzalutamide) in mCRPC Patients Previously Treated With Docetaxel and Who Rapidly Failed a Prior AR-targeted Agent (CARD)

Status: Completed
Phase of Trial: Phase IV

Latest Information Update: 13 Jun 2025

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At a glance

  • Drugs Cabazitaxel (Primary) ; Abiraterone acetate; Enzalutamide; Granulocyte colony-stimulating factors; Prednisone
  • Indications Adenocarcinoma; Prostate cancer
  • Focus Therapeutic Use
  • Acronyms CARD
  • Sponsors Sanofi

Most Recent Events

  • 30 Apr 2025 Results of prespecified sub-analysis presented at the 116th Annual Meeting of the American Association for Cancer Research.
  • 08 Jun 2021 Results of Fixed-effects frequentist ITCs were conducted using efficacy data from the prior taxane subgroup of PROfound (NCT02987543) and published data from the Phase IV CARD study of cabazitaxel versus NHA after prior NHA and taxane treatment (NCT02485691) presented at the 57th Annual Meeting of the American Society of Clinical Oncology
  • 29 Mar 2021 Status changed from active, no longer recruiting to completed.

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