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TCR-a/b+ and CD19+ Depleted KIR/KIR Ligand-mismatched Haploidentical Hematopoietic Stem Cell Transplant and Zoledronate for Pediatric Relapsed/Refractory Hematologic Malignancies and High Risk Solid Tumors

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Trial Profile

TCR-a/b+ and CD19+ Depleted KIR/KIR Ligand-mismatched Haploidentical Hematopoietic Stem Cell Transplant and Zoledronate for Pediatric Relapsed/Refractory Hematologic Malignancies and High Risk Solid Tumors

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 21 Oct 2025

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At a glance

  • Drugs Haematopoietic stem cell therapy (Primary) ; Zoledronic acid (Primary) ; Antithymocyte globulin; Fludarabine; Melphalan; Mycophenolate mofetil; Tacrolimus; Tacrolimus; Thiotepa
  • Indications Acute myeloid leukaemia; Bone metastases; Cancer metastases; Ewing's sarcoma; Graft-versus-host disease; Hodgkin's disease; Myelodysplastic syndromes; Myeloproliferative disorders; Neuroblastoma; Non-Hodgkin's lymphoma; Osteosarcoma; Precursor cell lymphoblastic leukaemia-lymphoma; Primitive neuroectodermal tumours; Rhabdomyosarcoma; Soft tissue sarcoma; Solid tumours
  • Focus Adverse reactions

Most Recent Events

  • 16 Oct 2025 Planned End Date changed from 1 Dec 2026 to 1 Dec 2027.
  • 16 Oct 2025 Planned primary completion date changed from 1 Dec 2025 to 1 Dec 2026.
  • 06 Nov 2024 Planned End Date changed from 1 Dec 2025 to 1 Dec 2026.

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