Trial Profile

A Phase III Randomized, Open-Label, Multi-Center, Global Study of MEDI4736 in Combination With Tremelimumab Therapy Versus Standard of Care Platinum-Based Chemotherapy in First-Line Treatment of Patients With Advanced or Metastatic Non Small-Cell Lung Cancer (NSCLC).

Status: Active, no longer recruiting

Phase of Trial: Phase III

Latest Information Update: 09 Apr 2025

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At a glance

Drugs Durvalumab (Primary) ; Tremelimumab (Primary) ; Carboplatin; Cisplatin; Gemcitabine; Paclitaxel; Pemetrexed
Indications Non-small cell lung cancer
Focus Registrational; Therapeutic Use
Acronyms NEPTUNE
Sponsors AstraZeneca; AstraZeneca AB

16 Jan 2025 Planned End Date changed from 31 Dec 2024 to 31 Dec 2025.
13 Feb 2024 Planned End Date changed from 29 Dec 2023 to 31 Dec 2024.
01 Apr 2023 Results of prespecified exploratory analysis (extended cohort enrolled in China) assessing efficacy and safety of durvalumab plus tremelimumab in patients with metastatic non-small-cell lung cancer, published in the Lung Cancer.

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