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A Study to Learn How Well the Drug Larotrectinib Works in Adults With Different Solid Cancers With a Change in the Genes Called NTRK Fusion

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Trial Profile

A Study to Learn How Well the Drug Larotrectinib Works in Adults With Different Solid Cancers With a Change in the Genes Called NTRK Fusion

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 17 Nov 2025

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At a glance

  • Drugs Larotrectinib (Primary)
  • Indications Advanced breast cancer; Anaplastic thyroid carcinoma; Appendiceal cancer; Biliary cancer; Carcinoma; Cholangiocarcinoma; CNS cancer; Colorectal cancer; Duodenal neoplasms; Gastric cancer; Glioma; Head and neck cancer; Liver cancer; Lung cancer; Male breast cancer; Malignant melanoma; Meningeal carcinomatosis; Neuroblastoma; Neuroepithelial neoplasms; Non-small cell lung cancer; Oesophageal cancer; Ovarian cancer; Pancreatic cancer; Renal cancer; Salivary gland cancer; Soft tissue sarcoma; Solid tumours; Squamous cell cancer; Thyroid cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms NAVIGATE
  • Sponsors Bayer; Loxo Oncology

Most Recent Events

  • 12 Nov 2025 Actual primary completion date changed to 29 September 2025.
  • 12 Nov 2025 Status changed from active, no longer recruiting to completed.
  • 01 Aug 2025 Planned primary completion date changed from 20 Jul 2025 to 31 Oct 2025.

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