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To study the effects of etanercept (TNF-blocker) on BMD and vertebral fractures in AS patients after two years of treatment. Additionally, changes in markers of bone turnover (CTXI, CTXII, RANKL, OPG, Osteocalcin) and radiological progression, including the thoracic spine, were studied during treatment with etanercept

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To study the effects of etanercept (TNF-blocker) on BMD and vertebral fractures in AS patients after two years of treatment. Additionally, changes in markers of bone turnover (CTXI, CTXII, RANKL, OPG, Osteocalcin) and radiological progression, including the thoracic spine, were studied during treatment with etanercept

Status: Completed
Phase of Trial: Phase IV

Latest Information Update: 23 Feb 2016

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At a glance

  • Drugs Etanercept (Primary)
  • Indications Ankylosing spondylitis
  • Focus Pharmacodynamics; Therapeutic Use

    • Most Recent Events

    • 15 Feb 2016 Results published in The Journal of Rheumatology
    • 15 Feb 2016 Primary endpoint "Bone mineral density (lumbar spine and hip)" has been met, as per the results published in The Journal of Rheumatology.
    • 02 Sep 2015 New trial record

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