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A Three-Arm Study of ME-401 Monotherapy in Subjects With Relapsed/Refractory CLL, SLL, or FL, of ME-401 in Combination With Rituximab in Subjects With Relapsed/Refractory CLL/SLL or B-cell NHL, and of ME-401 in Combination With Zanubrutinib in Subjects With Relapsed/Refractory CLL/SLL or B-cell NHL

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Trial Profile

A Three-Arm Study of ME-401 Monotherapy in Subjects With Relapsed/Refractory CLL, SLL, or FL, of ME-401 in Combination With Rituximab in Subjects With Relapsed/Refractory CLL/SLL or B-cell NHL, and of ME-401 in Combination With Zanubrutinib in Subjects With Relapsed/Refractory CLL/SLL or B-cell NHL

Status: Discontinued
Phase of Trial: Phase I

Latest Information Update: 21 Oct 2025

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At a glance

  • Drugs Rituximab (Primary) ; Zandelisib (Primary) ; Zanubrutinib (Primary)
  • Indications B-cell lymphoma; Chronic lymphocytic leukaemia; Diffuse large B cell lymphoma; Follicular lymphoma; Mantle-cell lymphoma; Marginal zone B-cell lymphoma; Non-Hodgkin's lymphoma
  • Focus Adverse reactions; Proof of concept
  • Sponsors Lite Strategy

Most Recent Events

  • 10 Sep 2025 According to MEI Pharma media release, MEI Pharma has changed its name to Lite Strategy.
  • 05 May 2023 Status changed from active, no longer recruiting to discontinued.
  • 13 Dec 2022 Results (n=50) assessing the safety and efficacy of zandelisib in combination with zanubrutinib in patients with relapsed/refractory follicular lymphoma (n=31; enrolled between Feb 2020 and Oct 2021) or mantle cell lymphoma (n=19; enrolled between Jan 2021 and May 2022), presented at the 64th American Society of Hematology Annual Meeting and Exposition.

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