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A Phase I/II Trial of Obinutuzumab, ABT-199 (GDC-0199) Plus Ibrutinib in Relapsed / Refractory Mantle Cell Lymphoma Patients

Trial Profile

A Phase I/II Trial of Obinutuzumab, ABT-199 (GDC-0199) Plus Ibrutinib in Relapsed / Refractory Mantle Cell Lymphoma Patients

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 14 Feb 2025

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At a glance

Most Recent Events

  • 15 Jun 2023 Updated results (n=48) assessing efficacy and toxicity of the Ibrutinib Obinutuzumab plus venetoclax combination in both R/R and untreated MCL patients presented at the 28th Congress of the European Haematology Association
  • 13 Dec 2022 Results by deriving tumor DNA from patients enrolled in the OAsIs trial, for assessing in vivo resistance to Ibrutinib/Venetoclax , presented at the 64th American Society of Hematology Annual Meeting and Exposition
  • 20 Nov 2020 To prevent tumor lysis syndrome (TLS), the protocol was amended to include an additional venetoclax ramp up cycle called cycle 1-b

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