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Proof-of-concept, Single Center Study in Healthy Adult Volunteers to Investigate Safety, Tolerability, Pharmacokinetics and Prophylactic Activity of Single Dose DSM265 in a Controlled Human Malarial Infection Challenge Either by Direct Venous Inoculation of Plasmodium Falciparum Sporozoites or Mosquito-borne Plasmodium Falciparum

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Trial Profile

Proof-of-concept, Single Center Study in Healthy Adult Volunteers to Investigate Safety, Tolerability, Pharmacokinetics and Prophylactic Activity of Single Dose DSM265 in a Controlled Human Malarial Infection Challenge Either by Direct Venous Inoculation of Plasmodium Falciparum Sporozoites or Mosquito-borne Plasmodium Falciparum

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 08 Apr 2022

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At a glance

  • Drugs DSM 265 (Primary)
  • Indications Falciparum malaria
  • Focus Proof of concept; Therapeutic Use

    • Most Recent Events

    • 05 Dec 2017 Primary endpoint (Time interval between challenge and the first positive parasitemia) has been met as per the results published in the Journal of Infectious Diseases.
    • 05 Dec 2017 Results published in the Journal of Infectious Diseases
    • 13 Jun 2017 Status changed from active, no longer recruiting to completed.

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