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A Phase III Study of Pembrolizumab (MK-3475) vs. Chemotherapy in Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Carcinoma (KEYNOTE-177)

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Trial Profile

A Phase III Study of Pembrolizumab (MK-3475) vs. Chemotherapy in Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Carcinoma (KEYNOTE-177)

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 19 Sep 2024

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At a glance

  • Drugs Pembrolizumab (Primary) ; Bevacizumab; Cetuximab; Fluorouracil; Folinic acid; Irinotecan; Levofolinic acid; Oxaliplatin
  • Indications Carcinoma; Colorectal cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms KEYNOTE-177; KN177
  • Sponsors Merck Sharp & Dohme Corp.

Most Recent Events

  • 19 Sep 2024 This trial has been completed in Spain (Global end date: 2023-07-07) according to European Clinical Trials Database record.
  • 10 Jun 2024 This trial has been completed in Ireland, according to the European Clinical Trials Database record.
  • 24 Oct 2023 Results (at data cutoff date: 17 Jul 2023) reporting efficacy and safety data at 5 years of follow-up presented at the 48th European Society for Medical Oncology Congress

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