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A Randomized, Observer-blind, Placebo-controlled, Phase 2 Study to Evaluate the Safety, Tolerability and Immunogenicity of Three Prime-boost Regimens of the Candidate Prophylactic Vaccines for Ebola Ad26.ZEBOV and MVA-BN-Filo in Healthy Adults, Including Elderly Subjects, HIV-infected Subjects, and Healthy Children in Two Age Strata in Africa

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Trial Profile

A Randomized, Observer-blind, Placebo-controlled, Phase 2 Study to Evaluate the Safety, Tolerability and Immunogenicity of Three Prime-boost Regimens of the Candidate Prophylactic Vaccines for Ebola Ad26.ZEBOV and MVA-BN-Filo in Healthy Adults, Including Elderly Subjects, HIV-infected Subjects, and Healthy Children in Two Age Strata in Africa

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 09 Mar 2022

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At a glance

  • Drugs Ad26 EBOV vaccine (Primary) ; Modified Vaccinia Ankara Bavarian Nordic Ebola Marburg vaccine (Primary)
  • Indications Ebola virus infections
  • Focus Adverse reactions
  • Sponsors Janssen; Janssen Vaccines and Prevention

    • Most Recent Events

    • 01 Jan 2022 Results published in the PLOS Medicine
    • 19 Mar 2019 Status changed from active, no longer recruiting to completed.
    • 17 Aug 2018 Planned primary completion date changed from 21 Jan 2019 to 7 Mar 2019.
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