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A Phase I/II Open-label, Multi-center Study of the Safety and Efficacy of IMCgp100 Using the Intra-patient Escalation Dosing Regimen in Patients With Advanced Uveal Melanoma

Trial Profile

A Phase I/II Open-label, Multi-center Study of the Safety and Efficacy of IMCgp100 Using the Intra-patient Escalation Dosing Regimen in Patients With Advanced Uveal Melanoma

Status: Completed
Phase of Trial: Phase I/II

Latest Information Update: 01 Jul 2024

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At a glance

  • Drugs Tebentafusp (Primary)
  • Indications Uveal melanoma
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms IMCgp100-102
  • Sponsors Immunocore

Most Recent Events

  • 04 Jun 2024 Results presented at the 60th Annual Meeting of the American Society of Clinical Oncology.
  • 01 Jun 2024 According to an Immunocore media release, clinical data for the treatment of patients with unresectable or metastatic uveal melanoma from this trial were presented at the 2024 ASCO (American Society for Clinical Oncology) Annual Meeting.
  • 24 Oct 2023 Results exploring effects of ImmTAC-redirected T cell activation on macrophage reprogramming using baseline and on-treatment tumor biopsies from this trial in mUM HLA-A*02:01+ patients treated with tebentafusp ; used to quantify CD163+ and CD3+ cells by immunohistochemistry, and to measure gene expression presented at the 48th European Society for Medical Oncology Congress

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