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A Phase Ib Study to Characterise the Antimalarial and Transmission Blocking Activity of a Single Dose of DSM265 or OZ439 in Healthy Subjects With Induced Blood Stage Plasmodium Falciparum or Plasmodium Vivax Infection
A Phase Ib Study to Characterise the Antimalarial and Transmission Blocking Activity of a Single Dose of DSM265 or OZ439 in Healthy Subjects With Induced Blood Stage Plasmodium Falciparum or Plasmodium Vivax Infection
Status:Discontinued
Phase of Trial:
Phase I
Latest Information Update:06 Nov 2021
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28 Jun 2021
Data from 4 studies (OZ439 monotherapy, DSM265 monotherapy;150 mg, DSM265 monotherapy; 400mg, OZ439/DSM265 combination therapy; 200mg of OZ439 combined with 50 and 100mg of DSM265) were used to evaluate efficacy by using within-host model, published in the Journal of Antimicrobial Chemotherapy
01 Jun 2020
Results (n=8) assessing PK/PD relationship of artefenomel using the P. vivax IBSM model and establishing the minimum dose of artefenomel required to clear P. vivax blood-stage parasitemia, published in the Journal of Infectious Diseases.
13 Jul 2016
Status changed from recruiting to discontinued.
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