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A Phase 1/2, Open-Label, Dose-Escalation And Expansion Study Of Entrectinib (Rxdx-101) In Pediatrics With Locally Advanced Or Metastatic Solid Or Primary CNS Tumors And/Or Who Have No Satisfactory Treatment Options

Trial Profile

A Phase 1/2, Open-Label, Dose-Escalation And Expansion Study Of Entrectinib (Rxdx-101) In Pediatrics With Locally Advanced Or Metastatic Solid Or Primary CNS Tumors And/Or Who Have No Satisfactory Treatment Options

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 27 Feb 2024

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At a glance

  • Drugs Entrectinib (Primary)
  • Indications CNS cancer; Neuroblastoma; Solid tumours
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms STARTRK-NG
  • Sponsors Roche
  • Most Recent Events

    • 22 Feb 2024 Planned primary completion date changed to 15 Jun 2025.
    • 01 Mar 2023 Results(n=43) assessing the pharmacokinetics of entrectinib and its active metabolite (M5) in pediatric patients published in the Cancer Chemotherapy and Pharmacology
    • 13 Jan 2023 Planned End Date changed from 30 Aug 2027 to 15 Jun 2025.
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