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A Phase 3 Randomized, Double-blind, Multi-center Study of Adjuvant Nivolumab Versus Placebo in Subjects With High Risk Invasive Urothelial Carcinoma (CheckMate 274: CHECKpoint Pathway and nivoluMAb Clinical Trial Evaluation 274)

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A Phase 3 Randomized, Double-blind, Multi-center Study of Adjuvant Nivolumab Versus Placebo in Subjects With High Risk Invasive Urothelial Carcinoma (CheckMate 274: CHECKpoint Pathway and nivoluMAb Clinical Trial Evaluation 274)

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 08 Apr 2024

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At a glance

  • Drugs Nivolumab (Primary)
  • Indications Bladder cancer; Carcinoma; Renal cancer; Ureteral neoplasms; Urogenital cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms CheckMate 274
  • Sponsors Bristol-Myers Squibb

    • Most Recent Events

    • 27 Jan 2024 Results of an analysis employed mixture cure models assessing underlying cure fraction among high-risk MIUC patients following radical resection in this trial presented at the 2024 Genitourinary Cancers Symposium
    • 17 Jan 2024 According to a Bristol-Myers Squibb media release, analyses of disease-free survival from this study will be presented in a late-breaking oral presentation at the American Society of Clinical Oncology 2024 Genitourinary Cancers Symposium (ASCO GU) to be held from January 25-27 in San Francisco, California.
    • 02 Jan 2024 Planned End Date changed from 15 May 2027 to 27 May 2027.

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