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Investigation of Metformin in Patients With Castration Resistant Prostate Cancer in Combination With Enzalutamide vs. Enzalutamide Alone (IMPROVE TRIAL): A Randomized, Open Label, Phase II Trial

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Trial Profile

Investigation of Metformin in Patients With Castration Resistant Prostate Cancer in Combination With Enzalutamide vs. Enzalutamide Alone (IMPROVE TRIAL): A Randomized, Open Label, Phase II Trial

Status: Discontinued
Phase of Trial: Phase II

Latest Information Update: 30 Jun 2023

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At a glance

  • Drugs Enzalutamide (Primary) ; Metformin
  • Indications Adenocarcinoma; Prostate cancer
  • Focus Therapeutic Use
  • Acronyms IMPROVE

Most Recent Events

  • 26 Jun 2023 Status changed from active, no longer recruiting to discontinued.
  • 13 Sep 2022 Primary endpoint has not been met. (Disease control (DC))
  • 13 Sep 2022 Results presented at the 47th European Society for Medical Oncology Congress

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