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A Phase 1/2, Open-Label, Multicenter Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of an Anti-CTLA-4 Human Monoclonal Antibody (AGEN1884) in Subjects With Advanced or Refractory Cancer and in Subjects Who Have Progressed During Treatment With a PD-1/PD-L1 Inhibitor as Their Most Recent Therapy

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A Phase 1/2, Open-Label, Multicenter Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of an Anti-CTLA-4 Human Monoclonal Antibody (AGEN1884) in Subjects With Advanced or Refractory Cancer and in Subjects Who Have Progressed During Treatment With a PD-1/PD-L1 Inhibitor as Their Most Recent Therapy

Status: Completed
Phase of Trial: Phase I/II

Latest Information Update: 20 Mar 2025

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At a glance

  • Drugs Zalifrelimab (Primary)
  • Indications Carcinoma; Liver cancer; Lymphoma; Solid tumours
  • Focus Adverse reactions; Pharmacokinetics
  • Sponsors Agenus

    • Most Recent Events

    • 28 Apr 2022 Status changed from active, no longer recruiting to completed.
    • 28 Dec 2021 Planned End Date changed from 15 Dec 2021 to 19 Dec 2023.
    • 28 Dec 2021 Planned primary completion date changed from 31 Oct 2021 to 31 Mar 2022.

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